Wellness for Life Blog – How Long Does Adderall Last? Adderall’s effects usually last between 4 to 6 hours, but factors like body chemistry can change that. Misuse can lead to anxiety, sleep problems, and addiction. Wellness for Life Blog explains how long Adderall lasts and what it means for your body. Learn to use it wisely and safely. Click through to get full, easy-to-read advice made for real users like you.