PAH is a rare but serious condition that affects the pulmonary vasculature, leading to increased resistance in the pulmonary arteries. This heightened resistance forces the heart to work harder to pump blood through the lungs, ultimately leading to right-sided heart failure if left untreated. Symptoms of PAH include shortness of breath, fatigue, chest pain, and fainting spells. The pathophysiology of PAH involves endothelial dysfunction, vasoconstriction, inflammation, and remodeling of the pulmonary arteries.
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